KATHY IRELAND
Welcome to WorldWide Business. I'm Kathy Ireland.
欢迎收看WorldWide Business，我是主持人Kathy Ireland。
Through incredible advancements in medical technology, the promise of personalized, precision medicine has never been closer to a reality than it is today. What makes this a possibility? Next Generation Sequencing.
随着医疗科技不断的进步和发展，个性化精准治疗从未像今天这样如此的接近现实生活。是什么让精准医疗变得如此的触手可及？是下一代测序技术。
Admera Health is a medical pioneer delivering next-generation, technology products for the advancement of our healthcare industry. Senior Scientific Liaison, Dr. Sue-Ann Woo, and Vice President, Brady Millican are here to talk about their innovative developments.
艾达康是新一代分子诊断公司，为推动人类健康事业不断发展下一代科技产品。艾达康高级科学联络官 Sue-Ann Woo博士 和副总裁Brady Millican将会在直播间和大家聊聊艾达康的创新成果。
Welcome to you both.
欢迎两位。
(Sue-Ann Woo responses)
Thank you for having us.
(Sue-Ann Woo 回答)
谢谢您的邀请。
(Brady Millican responses)
It is pleasure to be here.
(Brady Millican responses回答)
很高兴参加这次访谈。
KATHY IRELAND
A.Sue-Ann please tell us about Next Generation Sequencing and the complexities of sifting through the data it generates.
Sue-Ann 请给我们介绍下什么是下一代测序技术，以及下一代测序数据筛选的复杂性
(Sue-Ann responds)
Next Generation Sequencing or NGS, is massively parallel, high throughput DNA sequencing. With NGS technology, it is now possible to sequence billions of DNA bases, or the equivalent of multiple human genomes, in a single run for thousands of dollars per genome. In contrast, the Human Genome Project used a traditional sequencing method and took 13 years and $3 billion dollars to complete. NGS makes DNA sequencing faster, cheaper and more accurate than ever before. But the real challenge is storing and analyzing the data. Because the Next Generation Sequencing really generates an enormous amount of data. In order to really understand the data, you really need advanced bioinformatics analysis as well as expert in interpretation of the results.
(Sue-Ann 回答)
新一代测序也被称为NGS，指的是大规模平行和高通量DNA测序。随着NGS技术发展，一次花费数千美元的检测可以检测出几十亿对DNA碱基序列，这等同于几个个体携带的基因组全部信息。和下一代测序相比较，人类基因组计划所使用的传统测序方法则花费了13年的时间和30亿美元的费用。NGS让DNA测序变得更快捷、更经济、更精准。对于NGS而言，真正的挑战是如何存储和分析数据。因为NGS技术带来的是海量的信息，想要更好的解读数据，我们必须具备高级生物信息学技术和专业解读能力来分析测序结果。
KATHY IRELAND
Can you explain that please?
可以解释下吗？
(Sue-Ann responds)
Basically each human being has 3 billions of DNA bases. So it is kind of like looking for a needle in a haystack. We are looking for any variants and changes in that DNA, it is just a lot of data to sift through really, We need sophisticated bioinformatics analysis to align the genomic data and also to pinpoint what the different changes are.
(Sue-Ann 回答)
通常每个个体拥有30亿对DNA碱基对。因此检测DNA突变有点像大海捞针 ，我们想要找出DNA突变和变化信息，我们面临的是海量的数据，我们需要成熟的生物信息分析技术来整理基因信息数据，同时找出变异。
KATHY IRELAND
B.Sue-Ann, would you mind explaining how Admera Health is positioned to deliver Next Generation Sequencing?
Sue-Ann ，您是否可以介绍下艾达康是如何发展二代测序的？
(Sue-Ann responds)
We are well positioned, because early of this year, Admera expanded its state-of-the-art clinical laboratory as well as increased operations and bioinformatics capacity in order to support our Next Generation Sequencing based services. In addition, our R&D team is currently developing new products to really address the medical needs of the community.
(Sue-Ann 回答)
我们已做好准备，艾达康有着先进的实验室，今年对实验室进行了扩建，提升了运营能力和生物信息分析能力以保证NGS服务。另外，艾达康研发团队正在开发新的产品以满足医疗社区当下的需求。
Open Q&A
开放性问答环节
KATHY IRELAND
1.Brady, can you please tell us more about Admera Health?
Brady 是否可以介绍下艾达康其他相关情况？
(Brady responds) Admera Health was actually translational genetic division of a contract research organization called GENEWIZ. GENEWIZ has top pharm top biotech as our clients worldwide. So we were just small division of them. We almost 2 years old, this July first we gonna become 2 years old. We are very proud of the progress we made so far. We have several services already available to our physician clients. We are also very proud of that the Frost and Sullivan acknowledged us as 2016 Innovation Technology Award Winner for NGS.
(Brady 回答) 艾达康曾经是科研机构金唯智下属的转化基因部门。金唯智和全球范围内的顶级药商和生物研究公司有着良好的合作伙伴关系。艾达康当时只是金唯智一个小的小部门，到今年7月份，发展了快2年。我们对已经取得的发展成果引以为傲。目前艾达康已对医生推出多项服务项目。2016年，Frost and Sullivan授予我们创新技术大奖。
(KATHY IRELAND) Congratulations!
(KATHY IRELAND 回答) 恭喜你们！
(Brady responds)
Thank you very much.
So we think we are on pretty fast track to have good trajectory. When I said that I mean good trajectory helping patient outside in the field, give physician tools to help them with the precision medicine.
(Brady 回答)
谢谢。
我们一直认为艾达康进入了快速发展轨道，同时也朝着好的发展方向前行。我所说的发展方向指的是在医疗领域有效帮助患者，提供医生相关工具帮助患者，实现精准医疗。
KATHY IRELAND
Let's pause, and take a closer look at Admera's precision testing, in this WorldWide Business Field Report.
我们的访谈暂时告一段落，接下来请关注WorldWide Business 带来的现场报道--艾达康精准检测。
CUT TO: Field Report
镜头切换至现场报道
Next Generation Sequencing provides many challenges to the field of pharmacogenomics and inherited cardio vascular disease. Admera health is a leader in the NGS service space. They employ innovative technology and delivery results easy to read actionable reports.
下一代测序给药物基因组学和遗传心血管疾病带来了诸多挑战。艾达康是下一代测序行业领导者，采用领先的技术，提供的报告结果通俗易读，且具备可操作性。
(DR. JOHN KRipsAK responses)
I found their reports are very easy to read, very comprehensive and very physician friendly to read, and even patient friendly to read. And they are excellent source for comparing with other physicians may need the same information.
What kind of texting is done at Admera Health?
Genomics testing with salivary sampling. Gene sequencing to determine how our patient will tolerate of a variety medications. I trust Admera a lot, because they have strong history of efficacy in that field.
(DR. JOHN KRipsAK 回答)
我发现艾达康的报告内容全面且清晰易懂，不仅仅是对于医生而言，对患者而言也很方便理解。And they are excellent source for comparing with other physicians may need the same information.
艾达康需要什么类型的样品？
仅需口腔拭子样品即可进行基因检测。基因序列决定了患者对绝大数药物的耐受能力。我信任艾达康，因为在药物基因组检测领域艾达康的产品一直有着惊人的效果。
Admera Health is an advanced molecular diagnosis company focused on personalized medicine, non-invasive cancer testing and digital health. Their technology helps them to redefine disease screening, diagnosis, treatment, monitoring and management.
艾达康是新一代分子诊断公司，专注于个性化诊疗、无创癌症检测、数字健康等领域，致力于发展先进的诊断技术重新定义疾病的筛查、诊断、治疗、监控和管理。
2.Sue-Ann can you please give us an overview of pharmacogenomics testing?
Sue-Ann 是否可以介绍下药物基因组检测？
(Sue-Ann responds)
Pharmacogenomics testing analyzes genes that are related to drug metabolism & activity, which can influence how a person responds to certain medications. Our testing results can help guide treatment decisions, reducing adverse drug events - which are significant health problem. Adverse drug events can cause serious injury, hospitalization, and even death and are a huge financial burden on the US healthcare system.
(Sue-Ann 回答)
药物基因组检测是对影响药物代谢和活性的基因进行检测和分析，这些基因会影响个体对药物的反应。我们的检测结果可以帮助制定治疗方案，降低用药事故发生率。用药事故是很典型的问题，会给患者造成严重损伤、住院治疗，甚至会导致死亡，同时也会给美国医疗保健系统带来巨大的财务负担。
(KATHY IRELAND) For patient if taking multiple medications…
(KATHY IRELAND) 对于患者来说，如果采取多种药物治疗会……
(Sue-Ann responds)
Correct, it could be drug-drug interactions. But also we're really looking for to solving drug-gene interactions. Different people have variability in genes that can really affect how the drug is being processed in bodies. If it builds too much, it can lead to toxicity.
(Sue-Ann 回答)
是的，药物之间可能会发生药物反应。我们真正想解决的是药物和基因之间的关联反应。个体所携带的基因有很大差异性，正是这些基因决定着药物如何被身体吸收。如果某种成分在身体里积累太多，则会导致毒副反应。
(Jude Barbera)
It seems to me that giving the right does at the right time is really important. In past it was one-size fits all medicine. So winds up that. That only arrtibutes to that 40% of our patient actually reacts to medication, we found that genetically 60% is genetic preexist position that help them to metabolize drug. So it's that taking chances and again that's what we had. In the pass was putting someone on medication as to see if works or it didn't, change it or titrate the dosage over time. This is the answer before you start in most cases.
(Jude Barbera)
我认为在正确的时间给出正确的剂量是非常重要的。传统治疗方式是一种治疗方法应用于所有的治疗方案中。这种治疗方式该宣告结束了。因为我们发现在我们的患者中，有40%使用有效果， 另外的60%是遗传的基因帮助代谢药物。以前的方式是冒险式治疗，是给某位患者提供某种剂量的药物，然后再看是否有效，或者是通过滴定方式不断调整剂量。这也是许多患者所能获得的唯一方法。
(Richard Harkaway)
My personal experience was this which makes me start to do the pharmoco genomic testing Is that I was on my way to a standup comedy, that is my hobby. In my driveway I was ready drive to Manhattan from Philadelphia. My hands started to shake and my legs and my abdomen started to twisted. I stopped breathing and I collapsed. My？ on the garage. I stopped breathing. I am right to bite my wife and my kids in the ? on the floor. I started to breath showery, some guys walking through came and took me to the hospital, stop breath again and wake up in a different hospital (taken) by a helicopter. It was XXX not a stroke that I thought it was not a brain tumor I am back on. It turns out it is the drug I took, I am a slow metabolizer. The metabolizing the of the drug build up in my body more than it would in yours, we are taking the same dose of drug I am over-dosing myself, this byproduct gives me XXX . Now I am onboard with this more than any other things
(Richard Harkaway)
我有一次亲身经历，促使我做了药物基因组检测。 我喜欢看喜剧脱口秀，当时我正驾车前去观看一场喜剧脱口秀表演。在费城去往曼哈顿的驾车途中，我的手、脚开始颤抖，腹部绞痛，无法呼吸，然后瘫倒了。My？ on the garage.又不能呼吸了，然后开始咬我的妻子和孩子。然后是间歇性的呼吸。有人发现了我，送我去医院。醒来后，我发现自己在另外一家医院，是直升机送我去的。当时检测结果是？？？ 不是中风，我庆幸不是脑部肿瘤，活过来了。后来找到了原因，是我服用的一种药物引起的，我是慢速代谢者。这种药我吃下去后不能像正常人一样代谢，药物会在身体里累积。服用和正常人群同样的剂量，对于我来说就是过量服用，会导致我发病。一切都过去了，现在我一切正常，没有比这更重要的了。
3.Brady, please explain what makes your result reporting so different than others in the industry.
Brady 请您介绍下你们的报告结果和同行业其他竞争对手的报告不同之处。
(Brady responds) Ireland, our iconographic report format is the clearest and most concise in the industry. As Sue-Ann mentioned earlier that there are so much data, it really truly are presenting data to physicians, so you can understand it and it is distilling all the information down into a report that he can interpret, the physician can interpret it.
as well as be able to follow medically actionable data for the patients. In quite frankly we kind look forward to the consumer reading it as well. So it is kind of stop and go kind of format.
(Brady 回答) Ireland，我们的报告是以图表的形式展示结果，是业内最清晰简洁的报告。刚才Sue-Ann提到了下一代测序技术产生了海量的数据，需要将这些信息呈现给医生，并让医生理解。这就很有必要将数据挖掘和提炼到报告里，让医生能够解读，同时在治疗上对患者而言也易于接受。坦白讲，我们一直致力于让消费者也能够读懂报告。让报告真正的简单可行。
4.Brady, can you please share a physician's anecdotal story that describes how they've used the results in their practice?
Brady，能否分享一些案例来讲述下医生在实际治疗过程中是如何应用报告的？
(Brady responds) So I can tell you the story of one of our family practician doctors. They had a family come in, a family we meet with a mother and her two daughters. Two daughters were twins. They were on anti-depressives. They came to say their mom was feeling good, but the two girls were not. They all take the same drug. So we did a test on them. That not only we did confirm that their mother was taking the right drug as our analysis stated that. but we also found that the two girls even though they were twins, they needed different medications, but not the same medication for each of the girls, each of the girls needed a separate drug. Within weeks after that their mother called our physician and said what did you do, that was amazing. My girls are back, engaged in the high-school, having a great time, we feel more like a family. That is the power of our reporting.
(Brady 回答) 我们一位有经验的家庭医生分享过一个治疗故事。有一天他们接待了一个家庭，一位母亲和她的双胞胎女儿，他们在进行抗抑郁治疗。双胞胎女儿告诉我们他们服用的是同样的药物，母亲治疗效果很好，但是姐妹俩却没什么效果。我们给他们做了药物基因组检测。检测结果出来后，我们不仅印证了母亲的治疗方案是有效的，而且还发现姐妹俩应该采用不同的治疗方案，服用不同的药物，而不是采用相同的治疗方案。检测几周后母亲打电话给我们的医生，问我们用了什么方法，说太神奇了，姐妹俩好了，也融入进了学校生活，每天过得很开心，更像一家人了。 这就是我们的报告的神奇之处。
KATHY IRELAND
The advancements you're bringing to the medical industry are revolutionary; it certainly appears that Admera Health is impacting the future of healthcare.
你们给医疗行业带来革命性的进步。我们也看到艾达康的发展正在改变未来的医疗保健行业的模式。
Thank you both for joining us today.
感谢你们做客Worldwide Business。
(They both respond.)
(Sue-Ann Woo和Brady Millican回答)
Thank you for having us.
谢谢
KATHY IRELAND
For WorldWide Business, I'm Kathy Ireland. Thank you for watching.
这里是WorldWide Business。我是主持人Kathy Ireland。感谢您的收看。
