2016年6月6日 讯 /生物谷BIOON/ --近日，发表在2016年美国临床肿瘤学会年会上的一项研究报告中，来自美国凯斯西储大学（Case Western Reserve University）的研究人员通过研究发现，两种化疗药物的组合在抵御胰腺癌上或表现出巨大潜力，可以明显改善胰腺癌患者的5年生存率。
这项对732名患者进行的临床试验结果表明，胰腺癌患者在手术移除肿瘤组织后，利用口服药物卡培他滨和静脉注射药物吉西他滨组合的疗法或可明显改善患者的生存率，而且药物对患者机体的副作用并不会明显增加。
研究者Smitha Krishnamurthi表示，胰腺癌如今依然是非常难以治疗的癌症之一，本文研究就带来了一项巨大发现，通过加入一种遗传性化疗药物（卡培他滨）不仅可以改善患者的生存率，而且并不会对患者的生活质量产生任何影响。尽管很多被诊断为胰腺癌的患者并不适合进行手术治疗，但利用上述两种药物的组合性疗法或许就可以改善患者的生存率及生活质量。
研究者指出，进行药物卡培他滨和吉西他滨长达6个月的治疗可以使得胰腺癌患者的5年生存率达到28.8%，而进行吉西他滨治疗则仅会使得患者的5年生存率达到16.3%。两种药物组合治疗使得患者总的中位数存活率达到28个月，而仅使用吉西他滨治疗则使得患者总的中位数存活率达到25.5个月.
研究者Neoptolemos在一项声明中指出，两种不同的治疗方式所导致患者的生存中值差异并不明显，但在改善癌症患者长期生存率上却存在明显差别。本文研究发现，卡培他滨和吉西他滨疗法或许对于患者是安全的，而且也可以帮助研究者考虑添加其它药物来进行新型组合性疗法治疗。
据世界卫生组织数据显示，2012年全球有338，000位个体被诊断为胰腺癌，而且胰腺癌患者在北美和欧洲的数量最高。（生物谷Bioon.com）
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Two-drug regimen shows promise against pancreatic cancer
A combination of two chemotherapy drugs has shown promising results in fighting pancreatic cancer, significantly improving five-year survival rates, according to a European study presented Friday.
The trial showed that patients who take the oral drug capecitabine in addition to treatment with the commonly-used intravenous drug gemcitabine after surgical removal of pancreatic cancer survived longer without significant increase in negative side effects.
It was one of the largest trials ever conducted in pancreatic cancer, involving 732 patients.
The study was presented at the American Society of Clinical Oncology's annual meeting, the world's largest conference on cancer, currently being held in Chicago.
"Pancreatic cancer remains one of the most hard-to-treat cancers. It is a major win to find that adding a generic chemotherapy not only improves survival for these patients, but does so with little effect on patients' quality of life," said Smitha Krishnamurthi of Case Western Reserve University, who was not a part of the study.
Although most people diagnosed with pancreatic cancer are not candidates for surgery, the findings show that those who can have surgery "have a fighting chance of surviving this cancer with the combination of two commonly used chemotherapies," said John Neoptolemos, the study's lead author of the University of Liverpool in Britain.
